Otsuka Holdings Co., Ltd. Holding company Otsuka Pharmaceutical Co., Ltd. Manufacture, sales, import/export of pharmaceuticals, clinical testing and medical equipment, food products and cosmetics Otsuka Pharmaceutical Factory, Inc. Manufacture and sale of drugs (mainly clinical nutrition products), medical devices, and functional foods Taiho Pharmaceutical Co., Ltd. Manufacture, sales, import and export of pharmaceuticals and medical devices Otsuka Warehouse Co., Ltd. Warehousing and transport business Otsuka Chemical Co., Ltd. Manufacture and sales of chemical products Otsuka Foods Co., Ltd. Manufacture, sales, and import of foods and beverages Otsuka Medical Devices Co., Ltd. Integration of all business activities directly and indirectly related to the Otsuka Group's medical device business Otsuka Electronics Co., Ltd. Manufacture and sales of analysis and measurement equipment Otsuka Wellness Vending Co., Ltd. Sales of nutritional products and beverages through vending machine Nippon Pharmaceutical Chemicals Co., Ltd. Research and development and manufacture of pharmaceutical intermediates Otsuka Mechatronics Co., Ltd. Manufacture and sales of various types of testing equipment such as vehicle headlight testers Otsuka Techno Corporation Manufacture and sales of synthetic resin molded products EN Otsuka Pharmaceutical Co., Ltd. Manufacture and sales of pharmaceutical products J.O. Pharma Co., Ltd. Manufacture and sales of pharmaceutical products Otsuka Ridge Co., Ltd. Operation of Hotel Ridge and California Table Okayama Taiho Pharmaceutical Co., Ltd. Manufacture and sales of pharmaceutical products Otsuka Packaging Industries Co., Ltd. Manufacture and sales of paper products Dairin Integrated Transportation Co., Ltd. Warehousing and transport business HAIESU Service Co., Ltd. Transport business Otsuka Turftech Co., Ltd. Manufacture, sales and construction of artificial turf Otsuka Ohmi Ceramics Co., Ltd. Planning, design, production and construction of large ceramic boards, ceramic board masterpiece art, ceramic walls, reliefs, terracotta, OT ceramics, ceramic portraits and ceramic sign boards Higashiyama Film Co., Ltd. Processing and marketing of functional film Otsuka-MGC Chemical Company., Inc. Manufacture and sales of chemical products KiSCO Co., Ltd. Manufacture,import and sales of medical devices JIMRO Co., Ltd. Manufacture, sales, rental, export, import, research and development of medical devices Lilium Otsuka Co., Ltd. Research and development, manufacturing, and marketing of medical devices and related products Otsuka Digital Health Co., Ltd. Providing IT solution services Biomedical Solutions Inc. Research, development and manufacture of medical devices Earth Chemical Co., Ltd. Manufacture and sales, import/export of insecticide and toiletry products Earth Environmental Service Co., Ltd. General environmental health management NEOS Corporation Beverage sales activities through vending machines Nichiban Co., Ltd. Manufacturing and sales of adhesive tape for medical, stationary, industrial use

Otsuka Australia Pharmaceutical Pty Ltd. Import and sales of pharmaceutical proudcts Neurovance Australia Pty Ltd. Otsuka Beijing Research Institute Clinical development and research of pharmaceutical products Sichuan Otsuka Pharmaceutical Co., Ltd. Manufacture and sales of pharmaceutical products Zhejiang Otsuka Pharmaceutical Co., Ltd. Manufacture and sales of pharmaceutical products Otsuka (China) Investment Co., Ltd. Holding company Otsuka Shanghai Research Institute Research and development of pharmaceuticals Tianjin Otsuka Beverage Co., Ltd. Manufacture and sales of soft drinks and beverages Otsuka Sims (Guangdong) Beverage Co., Ltd. Manufacture and sales of soft drinks Suzhou Otsuka Pharmaceutical Co., Ltd. Manufacture and sales of pharmaceutical products Nanjing Otsuka Techbond Techno Co., Ltd. Manufacture and sales of synthetic resin molded products（3-layer film and 5-layer film） Shanghai Otsuka Foods Co., Ltd. Manufacture and sales of food products Zhangjiagang Otsuka Chemical Co., Ltd. Manufacture and marketing of flaky titanate and special compounds China Otsuka Pharmaceutical Co., Ltd. Manufacture and sales of pharmaceutical products Guangdong Otsuka Pharmaceutical Co., Ltd. Manufacture and sales of pharmaceutical products MicroPort Scientific Corporation Holding company Otsuka Pharmaceutical (H.K.) Ltd. Sales of pharmaceutical products and beverages Taiwan Otsuka Pharmaceutical Co., Ltd. Manufacture and sales of pharmaceutical products King Car Otsuka Co., Ltd. Manufacture and sales of beverages and foods Egypt Otsuka Pharmaceutical Co., S.A.E. Manufacture and sales of pharmaceutical products Otsuka Pharmaceutical India Private Limited Manufacture and sales of basic infusion and clinical nutrition products Otsuka Chemical (India) Private Limited Manufacture and sales of chemical products P.T. Amerta Indah Otsuka Manufacture and sales of soft drinks and beverages P.T. Otsuka Indonesia Manufacture and sales of pharmaceutical products P.T. Widatra Bhakti Manufacture and sales of pharmaceutical products P.T. Otsuka Jaya Indah Purchasing and sales of beverages and agricultural products P.T. Merapi Utama Pharma Purchasing and sales of pharmaceutical products and medical equipment P.T.Lautan Otsuka Chemical Manufacture and sales of chemical products PT Otsuka Distribution Indonesia Conducting business in large trading in general, including trade in import and export Diatranz Otsuka Limited Development and manufacturing of Xenotransplantation products Otsuka Pakistan Ltd. Manufacture and sales of pharmaceutical products Otsuka (Philippines) Pharmaceutical, Inc. Manufacture and sales of pharmaceutical and nutritional products OTSUKA-SOLAR Philippines Incorporated Import and sales of beverages and foods Korea Otsuka Pharmaceutical Co., Ltd. Manufacture and sales of pharmaceutical products Korea OIAA Co., Ltd. Pharmaceutical product promotion in Asia and the Middle East Otsuka Electronics Korea Co., Ltd. Import, manufacture and sales of analytical instruments and measuring instruments KOC Co., Ltd. Manufacture and marketing of hydrazine Dong-A Otsuka Co., Ltd. Manufacture and sales of beverages and foods Thai Otsuka Pharmaceutical Co., Ltd. Manufacture and sales of pharmaceutical products Abdi Ibrahim Otsuka Pharmaceutical Company Sales of pharmaceutical products Otsuka Thang Nutrition Co., Ltd. Sales of beverages and foods

Otsuka Canada Pharmaceutical, Inc. Sales and marketing of pharmaceutial products Daiya Foods Inc. Manufacture and sales of plant-based foods Otsuka America, Inc. Holding company Otsuka America Pharmaceutical, Inc. Manufacture and sales of pharmaceutical products Otsuka Pharmaceutical Development & Commercialization, Inc. Clinical development and commercialization of pharmaceutical products Otsuka Global Insurance, Inc. Reinsurance underwriting for the Otsuka Group Pharmavite LLC Manufacture and sales of nutritional products Ridge Vineyards, Inc. Manufacture and sales of wine Cambridge Isotope Laboratories, Inc. Manufacture and sales of reagents for research, such as stable isotopes Crystal Geyser Water Company Manufacture and sales of soft drinks and beverages Astex Pharmaceuticals, Inc. Clinical development of pharmaceutical products Avanir Pharmaceuticals, Inc. Developing, Production and sales of pharmaceutical products FoodState Inc. Production and sales of natural and whole food supplements ODH, Inc. Software and services to improve management of mental healthcare systems Taiho Oncology, Inc. Clinical development and commercialization of anticancer drugs Otsuka Chemical America, Inc. Manufacturing and selling Terracess (fiber-free potassium titanate) Crystal Geyser Brand Holdings, LLC Management of beverage brands CG Roxane LLC Manufacture and export of soft drinks and beverages ReCor Medical Inc. Research and development, manufacturing, and sales of medical devices Visterra, Inc. Research and development of phramceutical products A&P Inphatec Research and development, manufacture and sales of bio-pesticides

Jasmine Comercio de Produtos Alimenticios LTDA Production and sales of nutraceutical products

Interpharma Praha, a.s. Manufacture and sales of pharmaceutical and nutrition products Nardobel SAS Holding company Nutrition & Sante SAS Manufacturing and distributing of functional and dietetic foods Otsuka Pharmaceutical France SAS Purchasing and sales of pharmaceutical products ALMA S.A. Holding company of Alma Group, which manufactures and markets of spring water and mineral water Otsuka Pharma GmbH Purchasing and sales of pharmaceutical products Otsuka Novel Products GmbH Research and development related to tuberculosis Otsuka Pharmaceutical Italy S.r.l. Sales of pharmaceutical products Otsuka Pharmaceutical, S.A. Manufacture and sales of pharmaceutical products Hebron S.A. Manufacture and sales of industrial chemicals Trocellen Iberica S.A. Manufacture and marketing of polyolefin foams Otsuka Pharma Scandinavia AB Purchasing and sales of pharmaceutical products Otsuka Pharmaceutical (Switzerland) GmbH Sales of pharmaceutical products Otsuka Pharmaceutical Europe Ltd. Manufacture and sales of pharmaceutical products Otsuka Europe Development & Commercialisation, Ltd. Development of pharmaceutical products Otsuka Pharmaceuticals (U.K.) Ltd. Purchasing and sales of pharmaceutical products Astex Therapeutics, Ltd. Drug discovery research and development Veryan Holdings Ltd. Holding company